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Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle

Authors
  • Corwin D. Nelson (Iowa State University)
  • Donald C. Beitz (Iowa State University)
  • Timothy A. Reinhardt (United States Department of Agriculture)
  • John D. Lippolis (United States Department of Agriculture)

Abstract

We provide evidence that T-cell responses to Mycobacteria bovis are suppressed by the production of 1,25-dihydroxyvitamin D3 in monocytes and B-cells from cattle. Current vitamin D requirements for cattle are solely based on the classical endocrine mechanism of vitamin D signaling that regulates calcium homeostasis and should be re-evaluated to account for vitamin D signaling mechanisms in the immune system.

Keywords: ASL R2601

How to Cite:

Nelson, C. D., Beitz, D. C., Reinhardt, T. A. & Lippolis, J. D., (2011) “Regulation of Immune Responses to Mycobacteria bovis by a Paracrine Mechanism of Vitamin D Signaling in Cattle”, Iowa State University Animal Industry Report 8(1). doi: https://doi.org/10.31274/ans_air-180814-646

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Published on
2011-01-01

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