Characterization of a Multidrug-Resistant (MDR) Salmonella enterica Serovar I 4,[5], 12:i:- Isolate Associated with a 2015 Foodborne Outbreak from Pork
- B. Bearson (U.S. Department of Agriculture, Agricultural Research Service)
- B. Brunelle (U.S. Department of Agriculture, Agricultural Research Service)
- B. Kerr (U.S. Department of Agriculture, Agricultural Research Service)
- C. Loving (U.S. Department of Agriculture, Agricultural Research Service)
- D. Holman (U.S. Department of Agriculture, Agricultural Research Service)
- D. Shippy (U.S. Department of Agriculture, Agricultural Research Service)
- G. Tillman (U.S. Department of Agriculture, Agricultural Research Service)
- H. Allen (U.S. Department of Agriculture, Agricultural Research Service)
- J. Johnston (U.S. Department of Agriculture, Agricultural Research Service)
- J. Trachsel (U.S. Department of Agriculture, Agricultural Research Service)
- J. Wasilenko (U.S. Department of Agriculture, Agricultural Research Service)
- M. Simmons (U.S. Department of Agriculture, Agricultural Research Service)
- Nicholas K. Gabler (Iowa State University)
- S. Bearson (U.S. Department of Agriculture, Agricultural Research Service)
- S. Curry (U.S. Department of Agriculture, Agricultural Research Service)
- S. Sivasankaran (U.S. Department of Agriculture, Agricultural Research Service)
Abstract
Nontyphoidal Salmonella is a leading cause of bacterial foodborne disease in humans. Salmonella enterica serovar I 4,[5],12:i:- has emerged as the fourth most frequent cause of human salmonellosis in the U.S. based on 2015 National Antimicrobial Resistance Monitoring System (NARMS) data, and the most common multidrug-resistant (MDR; resistance to 3 or more antimicrobial classes) serovar with ~68 % of isolates being considered MDR (CDC, 2018). An MDR serovar I 4,[5],12:i:- outbreak was linked to pork in 2015 with 188 infections and 30 hospitalizations (Kawakami, et al. 2016); 523,380 pounds of pork were recalled. The pork outbreak-associated isolates were resistant to ampicillin, streptomycin, sulfisoxazole, and tetracycline (R-type ASSuT). Colonization and pathogenesis of a pork outbreak-associated serovar I 4,[5],12:i:- isolate in swine was consistent with trials conducted with virulent serovar Typhimurium, indicating that the increased prevalence of serovar I 4,[5],12:i:- is not due to an increase in pathogenesis (Shippy, et al. 2018). We sought to characterize strain FSIS1503788 associated with the pork outbreak and its derivatives using genomic, transcriptomic, and phenotypic analysis.
How to Cite:
Bearson, B., Brunelle, B., Kerr, B., Loving, C., Holman, D., Shippy, D., Tillman, G., Allen, H., Johnston, J., Trachsel, J., Wasilenko, J., Simmons, M., Gabler, N. K., Bearson, S., Curry, S. & Sivasankaran, S., (2019) “Characterization of a Multidrug-Resistant (MDR) Salmonella enterica Serovar I 4,[5], 12:i:- Isolate Associated with a 2015 Foodborne Outbreak from Pork”, SafePork 13(1), 67–68. doi: https://doi.org//safepork.11155
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