Proceedings

Is the porcine intestinal microvasculature not only permeable to nutrients but also to pathogens?

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Abstract

Salmonella Typhimurium penetrates the gut-vascular barrier in mice, gaining access to the bloodstream and liver (Spadoni et al, 2015). Despite it is still unknown how Salmonella Typhimurium disrupts the endothelial barrier, it is known that Plasmalemma Vesicle Associated Protein-1 (PV1), a measure of the “leakiness” of the endothelial barrier, is upregulated in blood capillaries upon Salmonella Typhimurium infection (Spadoni et al, 2016). PV1 is a component of the diaphragms found in endothelial fenestrae, transendothelial channels and caveolae (Stan et al, 2012). As only sparse data is available on porcine intestinal endothelium, the aim of the present study was to evaluate its ultrastructure with a focus on fenestration.

How to Cite:

Plendl, J. & Rieger, J., (2019) “Is the porcine intestinal microvasculature not only permeable to nutrients but also to pathogens?”, SafePork 13(1), 161. doi: https://doi.org//safepork.11408